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Symptoms and Treatment for Overdosage, and antidote(s): Doses of 200 mg per day for over a month have been reported to produce a pyridoxine dependency syndrome. Meanwhile high doses of pyridoxine (2-6 g/day) taken for several months have caused a severe sensory neuropathy. This condition seems to be reversible on withdrawal of pyridoxine.
Administration of Cyanocobalamin greater than 10 μg daily may produce a haematological response in patients with folate deficiency. Indiscriminate use may mask the precise diagnosis.
Since there is no specific antidote, treatment should be symptomatic and supportive and may include the following: To decrease absorption: Induction of emesis or use of gastric lavage to empty the stomach.
Supportive care: Maintenance of adequate hydration.
Patients in whom intentional overdose is confirmed or suspected should be referred for psychiatric consultation.
